The nicotine withdrawal was already reported in 1942. Abstinence from tobacco smoke and was described by Larson and Silvetti studies on tobacco published between 1961 and 1975.
The symptoms of withdrawal associated with cessation of tobacco use, however, were considered to be of psychological origin and inconsistent.
The absence of a withdrawal syndrome measured objectively and thus clearly defines the view has fueled a long time that smoking was not a form of addiction. Yes and ’so’ long believed that the symptoms defined from time to time through amendments of ritual behavior rather than the lack of nicotine.
The identification of aspects of the withdrawal syndrome that accompanies cessation of tobacco consumption and was launched in the late 70’s.
Several withdrawal symptoms (irritability, anxiety, hunger, urge to smoke) are nicotine-specific as shown by controlled trials using nicotine (2 mg) vs. placebo gum in order to characterize the withdrawal symptoms.
The withdrawal symptoms, ruling during the interruption of the consumption of tobacco, are part of those criteria used to define a nicotine-dependent smokers.
Like for other psychoactive substances are used by many parameters, including the signs of compulsive consumption, the presence of tolerance and withdrawal. Caused by the continuous intake of a substance (or substances), when they fail , triggers withdrawal symptoms, which has as consequences of the attacks of anxiety and irritability, impaired concentration and drowsiness, depression, increased hunger.
Nicotine is a very toxic substance: 50 mg (the contents of 2 packets of cigarettes), when taken in a single moment is a lethal dose.
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